Looc is from the Filipino/Onhan word look, meaning “bay”, referring to the body of water the town encloses. The first settlers of Looc where Onhan-speaking tribes from Panay Island which came around 1730.
The settlement was originally a barrio of the pueblo (town) of Cabolutan (located in present-day San Agustin) until 1790, when the town’s population was wiped-out by a smallpox epidemic and the town was abolished. The abolition transferred Looc under the administration of pueblo de Banton in Banton Island.
In the early 1800s, the settlement continued to progress and increase its population. Thus, in 1844, Spanish colonial authorities converted Looc into a full-pledged pueblo. Back then, Looc was still part of Capiz province, until 19 March 1853, when Romblon was officially declared a district separate from Capiz, and finally a full-pledged province in 1868.
Looc was one of the first four municipalities of the newly created province of Romblon, the other three being Romblon (capitol) Banton, and Sibuyan (Cajidiocan).